Z2876442907

Z2876442907
Clinical data
Drug classSerotonin 5-HT2A receptor agonist
ATC code
  • None
Identifiers
  • ethyl 2-[[2-(4-methyl-1H-indol-3-yl)ethylamino]methyl]-1,3-thiazole-5-carboxylate
PubChem CID
Chemical and physical data
FormulaC18H21N3O2S
Molar mass343.45 g·mol−1
3D model (JSmol)
  • CCOC(=O)C1=CN=C(S1)CNCCC2=CNC3=CC=CC(=C32)C
  • InChI=1S/C18H21N3O2S/c1-3-23-18(22)15-10-21-16(24-15)11-19-8-7-13-9-20-14-6-4-5-12(2)17(13)14/h4-6,9-10,19-20H,3,7-8,11H2,1-2H3
  • Key:DXXCNVVKOUYAQV-UHFFFAOYSA-N

Z2876442907 is a tryptamine derivative which acts as a serotonin 5-HT2A receptor agonist. It was discovered from a molecule docking screen against the AlphaFold model of the 5-HT2A receptor. As its 5-HT2A agonist activity has only been established in vitro, it is not yet established whether it produces psychedelic effects in animal models. It is structurally similar to other 5-HT2A agonist tryptamine derivatives such as 5-MeO-T-NBOMe and NEtPhOH-THPI, as well as the 5-HT6 antagonist idalopirdine.[1]

See also

References

  1. ^ Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, et al. (June 2024). "AlphaFold2 structures guide prospective ligand discovery". Science. 384 (6702) eadn6354. Bibcode:2024Sci...384n6354L. doi:10.1126/science.adn6354. PMC 11253030. PMID 38753765.
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