2-Methylmescaline

2-Methylmescaline
Clinical data
Other names2-Me-M; 2-Methyl-3,4,5-trimethoxyphenethylamine; 3,4,5-Trimethoxy-2-methylphenethylamine
Drug classSerotonin receptor modulator
ATC code
  • None
Identifiers
  • 2-(3,4,5-trimethoxy-2-methylphenyl)ethanamine
PubChem CID
Chemical and physical data
FormulaC12H19NO3
Molar mass225.288 g·mol−1
3D model (JSmol)
  • CC1=C(C(=C(C=C1CCN)OC)OC)OC
  • InChI=1S/C12H19NO3/c1-8-9(5-6-13)7-10(14-2)12(16-4)11(8)15-3/h7H,5-6,13H2,1-4H3
  • Key:PCULFTFEHMIRBM-UHFFFAOYSA-N

2-Methylmescaline (2-Me-M), also known as 2-methyl-3,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and scaline families related to mescaline.[1] It is the 2-methyl derivative of mescaline.[1] The drug shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 525 nM, 1,640 nM, and 1,094 nM, respectively).[1] These affinities were 5.7-fold, 2.8-fold, and 7.1-fold higher than those of mescaline, respectively.[1] The drug is not known to have been tested in animals or humans.[1] 2-Methylmescaline was first described in the scientific literature by Daniel Trachsel and colleagues in 2013.[1] The source of the information cited by Trachsel and colleagues was personal communication with David E. Nichols in 2010.[1]

See also

References

  1. ^ a b c d e f g Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 908–909. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
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