patch clamp

English

Noun

patch clamp (plural patch clamps)

  1. (biology) A device used to measure the ion currents in individual living cells.
    • 1978 July, Erwin Neher, Bert Sakmann, Joe Henry Steinbach, “The Extracellular Patch Clamp: A Method for Resolving Currents through Individual Open Channels in Biological Membranes”, in Pflügers Archiv, volume 375, →DOI:
      We have shown that the extracellular patch clamp can be reliably used to detect extremely small currents flowing through biological membranes.
    • 2025 Oct, William J Crumb Jr, Susan M Melnick, Kelli J Glenn, “The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses”, in Clin Transl Sci, volume 18, number 10, →DOI, →PMID, →PMCID:
      The effect of cenobamate on various human sodium channels (Nav1.1‐Nav1.8) was characterized using automated patch clamp on stably expressing cells (n = 3–4).
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