alcohol clamp

English

Noun

alcohol clamp (plural alcohol clamps)

  1. (physiology) A research procedure where ethanol is administered intravenously in order to keep a constant blood alcohol concentration over time.
    • 2001 March, J C Froehlich, R B Stewart, T K Li, A K Mosemiller, D E McCullough, M C Ho, J M Kisner, “Induction of steady-state blood alcohol levels: application to the study of within-session alcohol tolerance in rats”, in Alcohol Clin Exp Res, volume 25, number 3, →PMID, page 370:
      This study characterizes a method for maintaining steady-state blood alcohol levels over several hours in the rat, referred to as the "alcohol clamp."
    • 2006, Vijay A Ramchandani, Sean O’Connor, “Studying alcohol elimination using the alcohol clamp method”, in Alcohol Res Health, volume 29, number 4, →PMID, →PMCID:
      The alcohol clamp was developed to allow researchers to maintain a target BrAC in study participants despite these factors.
    • 2025 Mar, Sakiko Tsugawa, Fumihiko Ueno, Mutsuki Sakuma, Hideaki Tani, Ryo Ochi, Ariel Graff-Guerrero, Yoshihiro Noda, Hiroyuki Uchida, Masaru Mimura, Shunji Oshima, Sachio Matsushita, Shinichiro Nakajima, “Effects of short-term exposure to moderate amounts of alcohol on brain volume”, in Neuropsychopharmacol Rep, volume 45, number 1, →DOI, →PMID, →PMCID:
      An alcohol clamp method combined with physiologically based pharmacokinetic (PBPK) modeling is more suitable since this can achieve fine control over the rate, magnitude, and duration of exposure to alcohol within a range of 0.05 mg/mL.
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