Valiltramiprosate

Valiltramiprosate
Clinical data
Other names	ALZ-801; BLU8499
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 3-[[(2S)-2-amino-3-methylbutanoyl]amino]propane-1-sulfonic acid;
CAS Number	1034190-08-3;
PubChem CID	25008296;
DrugBank	DB19191;
ChemSpider	27819042;
UNII	GHG2B47067;
KEGG	D12218;
ChEMBL	ChEMBL4650301;
Chemical and physical data
Formula	C8H18N2O4S
Molar mass	238.30 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)[C@@H](C(=O)NCCCS(=O)(=O)O)N;
	InChI InChI=1S/C8H18N2O4S/c1-6(2)7(9)8(11)10-4-3-5-15(12,13)14/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13,14)/t7-/m0/s1; Key:NRZRFNYKMSAZBI-ZETCQYMHSA-N;

Valiltramiprosate is an investigational new drug that is being evaluated to treat early Alzheimer's disease.^[1] It is an amyloid precursor protein antagonist.^[2] Phase III results published in late 2025 suggested valiltramiprosate offered some benefit to certain patients genetically predisposed to Alzheimers, primarily when the drug was taken before those paients had developed dementia.^[3]

Valitramiprosate is being developed by drug maker Alzheon.

References

^ "Valiltramiprosate - Alzheon". AdisInsight. Springer Nature Switzerland AG.
^ Lee D, Antonsdottir IM, Clark ED, Porsteinsson AP (May 2024). "Review of valiltramiprosate (ALZ-801) for the treatment of Alzheimer's disease: a novel small molecule with disease modifying potential". Expert Opinion on Pharmacotherapy. 25 (7): 791–799. doi:10.1080/14656566.2024.2360069. PMID 38814590.
^ Hamilton J (29 October 2025). "An Alzheimer's pill appears to protect some in a high-risk population". NPR. Retrieved 29 October 2025.

[1] "Valiltramiprosate - Alzheon". AdisInsight. Springer Nature Switzerland AG.

[Lee_2024-2] Lee D, Antonsdottir IM, Clark ED, Porsteinsson AP (May 2024). "Review of valiltramiprosate (ALZ-801) for the treatment of Alzheimer's disease: a novel small molecule with disease modifying potential". Expert Opinion on Pharmacotherapy. 25 (7): 791–799. doi:10.1080/14656566.2024.2360069. PMID 38814590.

[3] Hamilton J (29 October 2025). "An Alzheimer's pill appears to protect some in a high-risk population". NPR. Retrieved 29 October 2025.

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