ONECUT1

ONECUT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	OMIM: 604164; MGI: 1196423; HomoloGene: 3309; GeneCards: ONECUT1; OMA:ONECUT1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,791,078 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	74,799,063 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right lobe of liver; ; gallbladder; ; testicle; ; islet of Langerhans; ; buccal mucosa cell; ; gonad; ; right testis; ; left testis; ; granulocyte;
	Top expressed in
	female urethra; ; wall of urinary bladder; ; mucosa of urinary bladder; ; urothelium; ; transitional epithelium of urinary bladder; ; liver; ; stroma of kidney; ; epithelium of female urethra; ; greater petrosal nerve; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; epithelial cell development; cell differentiation; cell fate commitment; endoderm development; regulation of transcription, DNA-templated; positive regulation of cell migration; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; spleen development; transcription by RNA polymerase II; transcription, DNA-templated; regulation of cell-matrix adhesion; glucose metabolic process; pancreas development; liver development; B cell differentiation; positive regulation of transcription by RNA polymerase II; organism system development; endocrine pancreas development; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	3175
	15379
	ENSG00000169856
	ENSMUSG00000043013
	Q9UBC0
	O08755
	NM_004498
	NM_008262
	NP_004489
	NP_032288
	Wikidata
View/Edit Human	View/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. ^[5]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. It is important for the differentiation of pancreas endocrine cells,^[6] and mutations in ONECUT1 are involved in juvenile diabetes.^[7] Alternative splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169856 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.
^ Heller, Sandra; Li, Zhijian; Lin, Qiong; Geusz, Ryan; Breunig, Markus; Hohwieler, Meike; Zhang, Xi; Nair, Gopika G.; Seufferlein, Thomas; Hebrok, Matthias; Sander, Maike; Julier, Cécile; Kleger, Alexander; Costa, Ivan G. (2021-11-17). "Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation". Communications Biology. 4 (1): 1298. doi:10.1038/s42003-021-02818-3. ISSN 2399-3642. PMC 8599846.
^ Philippi, Anne; Heller, Sandra; Costa, Ivan G.; Senée, Valérie; Breunig, Markus; Li, Zhijian; Kwon, Gino; Russell, Ronan; Illing, Anett; Lin, Qiong; Hohwieler, Meike; Degavre, Anne; Zalloua, Pierre; Liebau, Stefan; Schuster, Michael (November 2021). "Mutations and variants of ONECUT1 in diabetes". Nature Medicine. 27 (11): 1928–1940. doi:10.1038/s41591-021-01502-7. ISSN 1546-170X. PMC 9356324.

Function

References

Further reading