Magnesium L-threonate

Magnesium L-threonate
Names
	IUPAC name Magnesium bis[(2R,3S)-2,3,4-trihydroxybutanoate]
	Other names MgT
Identifiers
CAS Number	778571-57-6 ; 500304-76-7 (hydrate);
3D model (JSmol)	Interactive image;
ChemSpider	24590125 ;
PubChem CID	53395228;
CompTox Dashboard (EPA)	DTXSID30670457 ;
	InChI InChI=1S/2C4H8O5.Mg/c25-1-2(6)3(7)4(8)9;/h22-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t22-,3+;/m00./s1 Key: YVJOHOWNFPQSPP-BALCVSAKSA-L ; InChI=1/2C4H8O5.Mg/c25-1-2(6)3(7)4(8)9;/h22-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t22-,3+;/m00./s1 Key: YVJOHOWNFPQSPP-HSLCKNDHBH;
	SMILES [O-]C([C@H](O)[C@@H](O)CO)=O.[O-]C([C@H](O)[C@@H](O)CO)=O.[Mg+2];
Properties
Chemical formula	C8H14MgO10
Molar mass	294.495 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Magnesium L-threonate is a magnesium salt of L-threonic acid having the formula Mg(C₄H₇O₅)₂.^[1]

Magnesium L-threonate is purported to cross the blood-brain barrier more readily than regular magnesium ions,^[2] although no credible evidence proving the claim exists. No biological mechanism is proposed how magnesium ions would overcome the rapid physiological redistribution after reaching the brain, justifying targeted delivery.

Weak evidence shows that magnesium L-threonate improves cognitive function in healthy adults, although the trial did not compare its efficacy against conventional magnesium formulations.^[2]

References

^ Gao Sheng-Li;Yang Xu-Wu;Chen San-Ping;Ju Zhan-Feng (2002). "Synthesis and Standard Enthalpy of Formation of Magnesium L-Threonate". Acta Phys. -Chim. Sin. 18 (11): 994–997. doi:10.3866/PKU.WHXB20021107.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ ^a ^b Zhang, Chengxiang; Hu, Qi; Li, Shifen; Dai, Feifei; Qian, Wen; Hewlings, Susan; Yan, Ting; Wang, Yubang (2022-12-08). "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults". Nutrients. 14 (24): 5235. doi:10.3390/nu14245235. ISSN 2072-6643. PMC 9786204. PMID 36558392.

[1] Gao Sheng-Li;Yang Xu-Wu;Chen San-Ping;Ju Zhan-Feng (2002). "Synthesis and Standard Enthalpy of Formation of Magnesium L-Threonate". Acta Phys. -Chim. Sin. 18 (11): 994–997. doi:10.3866/PKU.WHXB20021107.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[:0-2] Zhang, Chengxiang; Hu, Qi; Li, Shifen; Dai, Feifei; Qian, Wen; Hewlings, Susan; Yan, Ting; Wang, Yubang (2022-12-08). "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults". Nutrients. 14 (24): 5235. doi:10.3390/nu14245235. ISSN 2072-6643. PMC 9786204. PMID 36558392.

[1]

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