METRNL

Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL).[1]

Lower serum levels of Metrnl might be a risk factor for developing coronary artery disease and type 2 diabetes mellitus[2][3]

References

  1. ^ Rao RR, Long JZ, White JP, et al. (2015). "Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis". Cell. 157 (6): 1279–1291. doi:10.1016/j.cell.2014.03.065. PMC 4131287. PMID 24906147.
  2. ^ Dadmanesh M, Aghajani H, Fadaei R, Ghorban K (2018). "Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines". PLOS ONE. 13 (9) e0204180. doi:10.1371/journal.pone.0204180. PMC 6136801. PMID 30212581.
  3. ^ Liu ZX, Ji HH, Yao MP, Wang L, Wang Y, Zhou P, Gao W (2019). "Serum Metrnl is associated with the presence and severity of coronary artery disease". Journal of Cellular and Molecular Medicine. 23 (1): 271–280. doi:10.1111/jcmm.13915. PMC 6307872. PMID 30394666.
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