JXL082

JXL082
Clinical data
Other names	JXL-082
Drug class	Mitochondrial pyruvate carrier (MPC) inhibitor
ATC code	None;
Identifiers
	IUPAC name ethyl (E)-3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-cyanoprop-2-enoate;
CAS Number	2260696-75-9;
ChEMBL	ChEMBL4746172;
Chemical and physical data
Formula	C22H15F6N3O2
Molar mass	467.371 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(=O)/C(=C/C1=CN(C2=C1C=CC=N2)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)/C#N;
	InChI InChI=1S/C22H15F6N3O2/c1-2-33-20(32)14(10-29)8-15-12-31(19-18(15)4-3-5-30-19)11-13-6-16(21(23,24)25)9-17(7-13)22(26,27)28/h3-9,12H,2,11H2,1H3/b14-8+; Key:AIPLDVOUZVHAOG-RIYZIHGNSA-N;

JXL082, or JXL-082, is a drug acting as a mitochondrial pyruvate carrier (MPC) inhibitor which was synthesized towards the aim of developing a treatment for hair loss.^[1]^[2] It is related to other drugs in the same series such as PP405, JXL069, and UK-5099 (JXL001).^[1]^[2] The drug is known to have been sold online in a grey market fashion for treatment of hair loss.^[2] It has been mistakenly believed to be PP405, but PP405 is said not to be JXL082.^[2] JXL082 was first described in the scientific literature by 2019.^[3]^[1]

References

^ ^a ^b ^c Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, et al. (February 2021). "Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss". Journal of Medicinal Chemistry. 64 (4): 2046–2063. doi:10.1021/acs.jmedchem.0c01570. PMC 8939290. PMID 33534563.
^ ^a ^b ^c ^d Brown L (12 August 2025). "The Great Unbalding Draws Nearer". Intelligencer. Retrieved 24 October 2025.
^ WO 2019006359A1, Lowry WE, Jung ME, Christofk H, Liu X, "Compositions and methods for modulating hair growth", published 3 January 2019, assigned to University of California Berkeley and University of California San Diego UCSD

[Liu_2021-1] Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, et al. (February 2021). "Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss". Journal of Medicinal Chemistry. 64 (4): 2046–2063. doi:10.1021/acs.jmedchem.0c01570. PMC 8939290. PMID 33534563.

[Brown_2025-2] Brown L (12 August 2025). "The Great Unbalding Draws Nearer". Intelligencer. Retrieved 24 October 2025.

[WO2019006359-3] WO 2019006359A1, Lowry WE, Jung ME, Christofk H, Liu X, "Compositions and methods for modulating hair growth", published 3 January 2019, assigned to University of California Berkeley and University of California San Diego UCSD

[1]

[2]

[3]

See also

References