Glycosylphosphatidylinositol diacylglycerol-lyase
| glycosylphosphatidylinositol diacylglycerol-lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.6.1.14 | ||||||||
| CAS no. | 129070-68-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction
- 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming].
Other names in common use include:
- GPI-PLC
- GPI-specific phospholipase C
- Glycosyl inositol phospholipid anchor-hydrolyzing enzyme
- Glycosylphosphatidylinositol-phospholipase C
- Glycosylphosphatidylinositol-specific phospholipase C or VSG-lipase[1]
- Variant-surface-glycoprotein phospholipase C
- 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
- Diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
References
- ^ Paturiaux-Hanocq, F.; Hanocq-Quertier, J.; de Almeida, M. L.; Nolan, D. P.; Pays, A.; Vanhamme, L.; Van den Abbeele, J.; Wasunna, C. L.; Carrington, M.; Pays, E. (2000-04-21). "A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei". The Journal of Biological Chemistry. 275 (16): 12147–12155. doi:10.1074/jbc.275.16.12147. ISSN 0021-9258. PMID 10766850.
- Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT (1986). "A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein". J. Biol. Chem. 261 (29): 13813–9. doi:10.1016/S0021-9258(18)67092-9. PMID 3759991.
- Carnall N, Webb H, Carrington M (1997). "Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei". Mol. Biochem. Parasitol. 90 (2): 423–32. doi:10.1016/S0166-6851(97)00177-1. PMID 9476790.
- Armah DA, Mensa-Wilmot K (2000). "Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei". J. Biol. Chem. 275 (25): 19334–42. doi:10.1074/jbc.M001798200. PMID 10764777.