Fadolmidine

Fadolmidine
Clinical data
Other namesMPV-2426; Radolmidine
ATC code
  • none
Legal status
Legal status
  • Not approved
Identifiers
  • N-[4-(acridin-9-ylamino)phenyl]-2-phenylacetamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC13H14N2O
Molar mass214.268 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53
  • InChI=1S/C27H21N3O/c31-26(18-19-8-2-1-3-9-19)28-20-14-16-21(17-15-20)29-27-22-10-4-6-12-24(22)30-25-13-7-5-11-23(25)27/h1-17H,18H2,(H,28,31)(H,29,30)
  • Key:KFOZTMBTDOTLMI-UHFFFAOYSA-N

Fadolmidine (development code MPV-2426) is an experimental α2 adrenergic receptor agonist that has been investigated as a spinal analgesic. It was developed with the aim of providing antinociceptive effects with reduced systemic side effects compared to other α2 agonists.[1]

Pharmacology

Fadolmidine acts as a selective α2 adrenergic receptor agonist, a receptor class associated with modulation of nociceptive signalling. A 2004 review described preclinical evidence of spinal antinociceptive effects in laboratory models and suggested a reduced propensity for sedation compared with systemic α2 agonists.[1]

Development

The compound was developed under the code MPV-2426. As of 2025, it has no approved medical indication and has not advanced to late-stage clinical development.[2]

Chemistry

Fadolmidine is an imidazole-derived compound structurally related to other α2 agonists such as medetomidine and dexmedetomidine.[1]

References

  1. ^ a b c Pertovaara A (2004). "Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist". CNS Drug Reviews. 10 (2): 117–126. doi:10.1111/j.1527-3458.2004.tb00008.x. PMC 6741742. PMID 15179442.
  2. ^ "Fadolmidine". AdisInsight. Springer Nature. Retrieved 2025-02-27.
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