Disufenton/acetylcysteine
| Combination of | |
|---|---|
| Disufenton sodium | Antioxidant |
| Acetylcysteine | Antioxidant |
| Clinical data | |
| Other names | Disufenton/N-acetylcysteine; HPN-07/NAC; NHPN-1010; NXY-059/NAC |
| Drug class |
|
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Unknown |
| Excretion | Unknown |
Disufenton/acetylcysteine (also known as HPN-07/NAC, NHPN-1010, or NXY-059/NAC) is an investigational combination therapy consisting of the nitrone free-radical trap disufenton sodium and the antioxidant N-acetylcysteine (NAC). It has been studied in preclinical research for noise-induced sensorineural hearing loss, tinnitus, cochlear synaptopathy, and traumatic brain injury, although as of 2024 there is no reported clinical development for any indication.[1]
Mechanism
Disufenton/acetylcysteine is described as acting through free-radical inhibition and oxygen-radical scavenging, processes relevant to oxidative stress injury in auditory and neural tissues.[2]
Rationale in auditory disorders
Oxidative stress and neuroinflammation contribute to noise induced cochlear injury, ribbon-synapse loss, and tinnitus-related neuronal hyperactivity.[3]
Tinnitus
Animal models have suggested that the combination may reduce behavioral correlates of tinnitus following noise trauma, likely via protection of inner-hair-cell synapses and reduction of neural hyperactivity.[4]
See also
References
- ^ "Disufenton/acetylcysteine – AdisInsight". AdisInsight / Springer Nature. Retrieved 2025-11-14.
- ^ Campbell K (2000). "Reduction of noise-induced hearing loss in chinchillas using N-acetylcysteine and acetyl-L-carnitine". Hearing Research. 149 (1–2): 138–146. doi:10.1016/s0378-5955(00)00176-3. PMID 11033253.
- ^ Kujawa SG, Liberman MC (February 2006). "Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth". The Journal of Neuroscience. 26 (7): 2115–2123. doi:10.1523/JNEUROSCI.4985-05.2006. PMC 1855187. PMID 16481444.
- ^ Falasca V, Greco A, Ralli M (2017). "Noise induced hearing loss: The role of oxidative stress". Otolaryngol Open J – via ResearchGate.