DIPK1B

DIPK1B
Identifiers
AliasesDIPK1B, C9orf136, pp6977, family with sequence similarity 69 member B, divergent protein kinase domain 1B, FAM69B
External IDsOMIM: 614543; MGI: 1927576; HomoloGene: 10516; GeneCards: DIPK1B; OMA:DIPK1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

138311

56279

Ensembl

ENSG00000165716

ENSMUSG00000036186

UniProt

Q5VUD6

Q99ML4

RefSeq (mRNA)

NM_152421

NM_019833

RefSeq (protein)

NP_689634

NP_062807

Location (UCSC)Chr 9: 136.71 – 136.72 MbChr 2: 26.52 – 26.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DIPK1B or divergent protein kinase domain 1B is a protein that in humans is coded by the DIPK1B gene.[5] It is a member of the FAM69 family, which consists of three members across all vertebrates other than fish. Is is also known as FAM69B.[6]

Gene

The DIPK1B gene is found on human chromosome 9, in the 9q34.3 band.[6] The gene is located on the plus strand and spans 12,275 bases.[7] The gene contains five exons. It is a member of FAM69, a family of genes with three members, DIPK1A, DIPK1B, and DIPK1C.[8] This family is present in all vertebrates, with slight differences in fish, and orthologs of highly conserved structure are found in all metazoa.[8]

Transcripts

In humans there is only one known DIPK1B transcript. The mRNA transcript of DIPK1B is 2358 bases long, and contains all five exons of the DIPK1B gene.[9]

Protein

Human DIPK1B has only one isoform. The resultant protein is 431 amino acids long, has an isoelectric point of 9, and has a predicted molecular weight of 48.6 kDa.[5][12] DIPK1B contains two distinct domains, a transmembrane domain and a protein kinase domain.[5]

Expression

DIPK1B exhibits variable ubiquitous expression at moderate to high levels.[13] Expression in the brain, heart, and lung is notably higher than in other tissues. [6]

Regulation

DIPK1B is localized to the membrane of the endoplasmic reticulum.[8] It is expected to undergo a number of post-translational modifications, including o-linked glycosylation, phosphorylation, ubiquitination, and acetylation.[14]

Homology

DIPK1B Orthologs
Genus and Species Common Name Taxonomic Group Date of Divergence (MYA) Accession Number Sequence Length (aa) Sequence Identity to Human Protein (%) Sequence Similarity to Human Protein (%)
Homo sapiens Humans Primates 0 NP_689634 431 100 100
Gorilla gorilla gorilla Gorilla Primates 8.6 XP_004048941.2 431 99.5 99.5
Desmodus rotundus Vampire bat Mammals 94 XP_053775135 435 84.9 90.7
Dromiciops gliroides Monito del monte Marsupials 160 XP_043845610.1 431 71.2 83.5
Gopherus flavomarginatus Bolson tortoise Reptiles 319 XP_050782714.1 431 68.2 82.6
Tiliqua scincoides Common blue-tongued skink Reptiles 319 XP_066466737.1 431 66.8 81.4
Varanus komodoensis Komodo dragon Reptiles 319 XP_044309118.1 431 65.7 90
Cyrtonyx montezumae Montezuma quail Birds 319 XP_065593300.1 431 67.5 82.6
Gallus gallus Chicken Birds 319 XP_415423 431 67.3 82.4
Taeniopygia guttata Australian zebra finch Birds 319 XP_002199526.4 431 66.1 81.7
Geothlypis trichas Common yellowthroat Birds 319 KAL9827061.1 431 65.9 82.4
Ambystoma mexicanum Axolotl Amphibians 352 XP_069465698.1 431 67.5 81
Ascaphus truei Tailed Frog Amphibians 352 XP_075435024 431 66.1 82.6
Xenopus laevis African clawed frog Amphibians 352 XP_018088073.1 431 62.9 80.3
Protopterus annectens West African Lungfish Fish 408 XP_043914470 431 65.4 82.4
Hypanus sabinus Atlantic stingray Fish 462 XP_059850265.1 431 61.5 80.3
Callorhinchus milii Australian ghostshark Fish 462 XP_042193771.1 431 60.8 78.4
Amblyraja radiata Thorny skate Fish 462 XP_032904599 431 58.9 79.1
Magallana gigas Pacific Oyster Mollusks 686 XP_011453093.2 438 23.7 40
Anopheles gambiae Mosquito Insects 686 XP_061498526 427 23 37.3

Function

DIPK1B has been shown to interact with SAT1 and SLC39A12.[15]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036186 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "NCBI Protein - divergent protein kinase domain 1B [Homo sapiens]". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  6. ^ a b c "NCBI Gene - DIPK1B divergent protein kinase domain 1B [Homo sapiens (human)]". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  7. ^ "GeneCards- DIPK1B Gene". Retrieved 2025-09-08.
  8. ^ a b c Tennant-Eyles, Anthea J.; Moffitt, Hilary; Whitehouse, Caroline A.; Roberts, Roland G. (2011-03-18). "Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins". Biochemical and Biophysical Research Communications. 406 (3): 471–477. Bibcode:2011BBRC..406..471T. doi:10.1016/j.bbrc.2011.02.076. ISSN 0006-291X. PMID 21334309.
  9. ^ "NCBI Nuccore - Homo sapiens divergent protein kinase domain 1B (DIPK1B), mRNA". 27 April 2025. Retrieved 2025-09-08.
  10. ^ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2025-12-04.
  11. ^ "iCn3D: Web-based 3D Structure Viewer". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  12. ^ "Expasy - Compute pI/Mw tool". web.expasy.org. Retrieved 2025-12-04.
  13. ^ "GDS3113 / 137763". www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
  14. ^ "DIPK1B (human)". www.phosphosite.org. Retrieved 2025-12-04.
  15. ^ "IntAct Portal". www.ebi.ac.uk. Retrieved 2025-12-12.
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