Cyclobutrifluram

Cyclobutrifluram
Names
	Preferred IUPAC name N-[(1R,2R)-2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide
Identifiers
CAS Number	1460292-16-3;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:192261;
ChemSpider	128920200;
ECHA InfoCard	100.307.361
EC Number	942-593-7;
PubChem CID	71766128;
UNII	8M88L532QV;
	InChI InChI=1S/C17H13Cl2F3N2O/c18-9-3-4-10(13(19)8-9)11-5-6-14(11)24-16(25)12-2-1-7-23-15(12)17(20,21)22/h1-4,7-8,11,14H,5-6H2,(H,24,25)/t11-,14-/m1/s1 Key: GBFKIHJZPMECCF-BXUZGUMPSA-N;
	SMILES C1C[C@H]([C@H]1C2=C(C=C(C=C2)Cl)Cl)NC(=O)C3=C(N=CC=C3)C(F)(F)F;
Properties
Chemical formula	C17H13Cl2F3N2O
Molar mass	389.20 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Cyclobutrifluram is a chemical compound which acts as a nematicide and also shows antifungal effects against Fusarium species. It was first approved for agricultural use in 2025.^[1] Concerns have been raised about cyclobutrifluram and several other recently approved pesticides due to their high persistence in the environment and metabolism to polyfluoroalkyl substances (PFAS) such as trifluoroacetic acid.^[2]

References

^ Flemming, A; Guest, M; Luksch, T; O'Sullivan, A; Screpanti, C; Dumeunier, R; Gaberthüel, M; Godineau, E; Harlow, P; Jeanguenat, A; Kurtz, B; Maienfisch, P; Mondière, R; Pierce, A; Slaats, B; Smejkal, T; Loiseleur, O (May 2025). "The discovery of Cyclobutrifluram, a new molecule with powerful activity against nematodes and diseases". Pest Manag Sci. 81 (5): 2480–2490. Bibcode:2025PMSci..81.2480F. doi:10.1002/ps.8730. PMID 40007473.
^ Erickson BE. 4 new pesticides ignite debate over PFAS definition. Chemical and Engineering News 14 July 2025

[1] Flemming, A; Guest, M; Luksch, T; O'Sullivan, A; Screpanti, C; Dumeunier, R; Gaberthüel, M; Godineau, E; Harlow, P; Jeanguenat, A; Kurtz, B; Maienfisch, P; Mondière, R; Pierce, A; Slaats, B; Smejkal, T; Loiseleur, O (May 2025). "The discovery of Cyclobutrifluram, a new molecule with powerful activity against nematodes and diseases". Pest Manag Sci. 81 (5): 2480–2490. Bibcode:2025PMSci..81.2480F. doi:10.1002/ps.8730. PMID 40007473.

[2] Erickson BE. 4 new pesticides ignite debate over PFAS definition. Chemical and Engineering News 14 July 2025

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