Céline Gongora
Céline Gongora | |
|---|---|
| Born | 1972 (age 52–53) |
| Citizenship | French |
| Alma mater | Montpellier 2 University, currently University of Montpellier |
| Known for |
|
| Scientific career | |
| Fields | Molecular Biology, Cancer Research |
| Institutions | ICRM, University of Montpellier |
| Thesis | Identification et caractérisation d'un nouveau gène induit par les IFNs : isg20 (1999) |
| Academic advisors | Nadir Mechti |
Céline Gongora is a French cancer researcher and molecular biologist known for the discovery of Interferon-stimulated gene 20 kDa protein[1] as well as her work on drug resistance in solid tumours, particularly colorectal and prostate cancers. She is a research director at the Institut de Recherche en Cancérologie de Montpellier (IRCM), part of the University of Montpellier, where she leads the “Drug Resistance and New Cancer Treatment” team.[2]
During her PhD in the lab of Nadir Mechti she was part of the team who discovered ISG20, an important RNA exonuclease.[3] This structural characterisation work enabled later identification of ISG20 as a major component involved in antiviral innate immunity, involvement in cancer proliferation as well as potential therapeutic applications of ISG20 in acute-kidney injury treatment.[4]
References
- ^ Deymier, Séverine; Louvat, Camille; Fiorini, Francesca; Cimarelli, Andrea (June 2022). "ISG20: an enigmatic antiviral RNase targeting multiple viruses". FEBS Open Bio. 12 (6): 1096–1111. doi:10.1002/2211-5463.13382. PMC 9157404.
- ^ "Drug resistance and new cancer treatments : C. Gongora". IRCM.
- ^ Gongora, Celine; David, Gregory; Pintard, Lionel; Tissot, Catherine; Hua, The Duc; Dejean, Anne; Mechti, Nadir (1997). "Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein". Journal of Biological Chemistry. 272 (31): 19457–19463. doi:10.1074/jbc.272.31.19457. PMID 9235947.
- ^ Jia, Meng; Li, Liang; Chen, Ruiqi; Du, Junyao; Qiao, Zhe; Zhou, Di; Liu, Min; Wang, Xiaojie; Wu, Jichao; Xie, Yusheng; Sun, Yu; Zhang, Yan; Wang, Ziying; Zhang, Tao; Hu, Huili; Sun, Jinpeng; Tang, Wei; Yi, Fan (October 2023). "Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury". Molecular Therapy : The Journal of the American Society of Gene Therapy. 31 (10). CellPress: 3034–3051. doi:10.1016/j.ymthe.2023.07.008. PMC 10556188. PMID 37452495.
External links
Gongora, Céline. "Scopus ID". sciencedirect.com.