Brachyspira holin family

The Brachyspira holin (B-Hol) Family (TC# 1.E.55) consists of several proteins from the GTA holin of Brachyspira hyodysenteriae (TC# 1.E.55.1.1), which facilitates gene transfer agent-release (see also GTA holin family) to VSH-1 holin of Brachyspira pilosicoli. VSH-1 is thought to participate in cell lysis. These proteins range in size from about 85 to 145 amino acyl residues (aas) and exhibit between 2 and 4 transmembrane segments (TMSs). A representative list of proteins belonging to the B-Hol family can be found in the Transporter Classification Database.^[1]

• Holin
• Lysin
• Transporter Classification Database

• Matson, EG; Thompson, MG; Humphrey, SB; Zuerner, RL; Stanton, TB (2005). "Identification of genes of VSH-1, a prophage-like gene transfer agent of Brachyspira hyodysenteriae". J Bacteriol. 187: 5885–92. doi:10.1128/JB.187.17.5885-5892.2005. PMC 1196157. PMID 16109929..
• Reddy, BL; Saier, MH (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochim. Biophys. Acta. 1828: 2654–71. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191..
• Saier, MH; Reddy, BL (2015). "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications". J. Bacteriol. 197: 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079..
• Wang, IN; Smith, DL; Young, R (2000). "Holins: the protein clocks of bacteriophage infections". Annu. Rev. Microbiol. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145..

As of this edit, this article uses content from "1.E.55 The Brachyspira holin (B-Hol) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.