Bacterial archaeal holin family

The Putative Bacterial Archaeal Holin (BAH) Family (TC# 9.B.185) consists of several uncharacterized proteins. However, these proteins were retrieved when functionally characterized holins from the T-A Hol family (TC# 1.E.43) were BLASTED against the NCBI database, and thus may be related to the T-A Hol family. Most BAH proteins are between 125 and 140 amino acyl residues (aas) in length and exhibit 4 transmembrane segments (TMSs), although at least one putative holin (TC# 9.B.185.1.4) is almost 260 aas long. A representative list of proteins belonging to the BAH family can be found in the Transporter Classification Database.^[1]

• Holin
• Lysin
• Transporter Classification Database

• Reddy, BL; Saier, MH (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochim. Biophys. Acta. 1828: 2654–71. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191..
• Saier, MH; Reddy, BL (2015). "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications". J. Bacteriol. 197: 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079..
• Wang, IN; Smith, DL; Young, R (2000). "Holins: the protein clocks of bacteriophage infections". Annu. Rev. Microbiol. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145..
• Young, R; Bläsi, U (1995). "Holins: form and function in bacteriophage lysis". FEMS Microbiol. Rev. 17: 191–205. PMID 7669346..

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