Andrzej Mikołaj Pilc

Andrzej Mikołaj Pilc
Andrzej Pilc
Born(1948-04-20)20 April 1948
Łódź, Poland
CitizenshipPolish
Alma materMedical University of Łódź
Occupationneuropharmacologist
EmployerMaj Institute of Pharmacology of the Polish Academy of Sciences

Andrzej Mikołaj Pilc (born 20 April 1948[1]) - polish neuropharmacologist[2] specializing in the psychopharmacology of anxiety and depression, professor at the Maj Institute of Pharmacology of the Polish Academy of Sciences in Krakow[3], and author of over five hundred scientific publications[4]. He is a professor of medical sciences, a corresponding member of Division V of the Polish Academy of Sciences, an active member of the Medical Division of the Polish Academy of Arts and Sciences (PAU), and a researcher of metabotropic glutamate receptors. His scientific achievements include participation in discovering increased expression of GABA B receptors under the influence of antidepressants[5] and the antidepressant and anxiolytic effects of mGluR5 metabotropic glutamate receptor antagonists[6][7][8].

Scientific career

Scientific development

In 1972, he obtained his medical degree at the Medical Academy in Łódź[2]. In 1977, he obtained Ph. D. degree at the Faculty of Medicine of the same academy. After obtaining his diploma, he completed postdoctoral internships at the Biological Research Centre of the Hungarian Academy of Sciences in Szeged, Hungary (1975-1976), at LERS-Synthelabo in Paris, France (1982-1983) and at the University of Texas (1984-1986)[9].

In 1987, he received his habilitation degree with a specialization in experimental pharmacology at the Faculty of Medicine of the Medical Academy in Łódź. In 1992-1994, he worked as an associate professor at the Medical School of Kuwait University[9]. In 1997, he was awarded the title of professor of medical sciences[2].

He served as head of the Department of Neurobiology at the Maj Institute of Pharmacology of the Polish Academy of Sciences in Krakow (1991–2019) and head of the Department of Drug Management at the Faculty of Public Health of the Jagiellonian University Medical College in Krakow (1997–2019)[9].

Scientific work

During his postdoctoral fellowship at Synthelabo in Paris, he published papers on the effects of antidepressants and electroconvulsive therapy on metabotropic γ-aminobutyric acid (GABA B), which play a significant role in the pathophysiology of depression[10]. He is co-author of studies indicating the involvement of α2-adrenergic receptors in the mechanism of action of antidepressants[11][12] and a number of articles on the effects of histamine on the brain[13][14].

In the 1990's, he began researching metabotropic glutamate receptors (mGluRs)[15], contributing to the discovery of the anxiolytic, antidepressant and anti-Parkinson's[16] effects of ligands targeting these receptors. Later, his research focused on enhancing the antidepressant effects of hallucinogens through the modulation of mGluR ligands[17][18][19]. He was listed among the top 2% most cited scientists in the world, ranking 891st out of 140,593 researchers in the field of pharmacology[20][21][22].

He is also known for his work in the field of scientometrics, especially as the creator of the first ranking of Polish scientists based on citation indices[23].

Awards

He has received numerous prestigious awards throughout his career. In 2003 he was honored with the Tadeusz Browicz Award from the Faculty of Medical Sciences of the Polish Academy of Arts and Sciences[24]. In 2008 he received the Jędrzej Śniadecki Award from the Faculty of Medical Sciences of the Polish Academy of Sciences[25] and in 2019 the Jędrzej Śniadecki Medal[26]. Additionally, in 2004 he was awarded the Golden Cross of Merit[27]. Ranked as Poland's top medical scientist by Top Medicine Scientists in 2022[28].

References

  1. ^ "Prof. dr hab. Andrzej Pilc" (in Polish). PAN. Retrieved 2025-10-13.
  2. ^ a b c "Prof. dr hab. Andrzej Pilc" (in Polish). Ludzie Nauki. Retrieved 2025-10-13.
  3. ^ "Prof. dr hab. Andrzej Pilc" (in Polish). Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk. Retrieved 2025-10-13.
  4. ^ "Prof. dr hab. Andrzej Pilc" (in Polish). Google Scholar. Retrieved 2025-10-13.
  5. ^ A. Pilc, K. G. Lloyd (1984), "Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action", Life Sciences, 35 (21): 2149–2154, doi:10.1016/0024-3205(84)90515-0, PMID 6092815
  6. ^ Ewa Tatarczyńska, Aleksandra Kłodzińska, Ewa Chojnacka-Wójcik, Agnieszka Pałucha, Fabrizio Gasparini, Rainer Kuhn, Andrzej Pilc (2001), "Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist", British Journal of Pharmacology, 132 (7): 1423–1430, doi:10.1038/sj.bjp.0703923, PMC 1572682, PMID 11264235{{citation}}: CS1 maint: multiple names: authors list (link)
  7. ^ Agnieszka Palucha, Andrzej Pilc (2007), "Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs", Pharmacology & Therapeutics, 115 (1): 116–147, doi:10.1016/j.pharmthera.2007.04.007, PMID 17582504
  8. ^ Andrzej Pilc, Joanna M. Wierońska, Phil Skolnick (2013), "Glutamate-based antidepressants: preclinical psychopharmacology", Biological Psychiatry, 73 (12): 1125–1132, doi:10.1016/j.biopsych.2013.01.021, PMID 23453290{{citation}}: CS1 maint: multiple names: authors list (link)
  9. ^ a b c "Brief Bio Andrzej Pilc" (in Polish). Loop. Retrieved 2025-10-19.
  10. ^ K. G. Lloyd, F. Thuret, A. Pilc (1985), "Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock", The Journal of Pharmacology and Experimental Therapeutics, 235 (1): 191–199, doi:10.1016/S0022-3565(25)23855-1, PMID 2995646{{citation}}: CS1 maint: multiple names: authors list (link)
  11. ^ A. Pilc, S. J. Enna (1986), "Activation of alpha-2 adrenergic receptors augments neurotransmitter-stimulated cyclic AMP accumulation in rat brain cerebral cortical slices", The Journal of Pharmacology and Experimental Therapeutics, 237 (3): 725–730, doi:10.1016/S0022-3565(25)24857-1, PMID 2872324
  12. ^ A. Pilc, S. J. Enna (198), "Synergistic interaction between alpha- and beta-adrenergic receptors in rat brain slices: possible site for antidepressant drug action", Life Sciences, 37 (13): 1183–1194, doi:10.1016/0024-3205(85)90129-8, PMID 2995740
  13. ^ C. Maśliński, B. Bielkiewicz, J. Z. Nowak, A. Pilc (1975), "Histamine content and synthesis in central and pheripheral nerve structures during stress", Agents and Actions, 5 (1): 4–8, doi:10.1007/BF02027150, PMID 1180176{{citation}}: CS1 maint: multiple names: authors list (link)
  14. ^ J.Z. Nowak, A. Pilc, U. Lebrecht, C. Maśliński (1977), "Does histamine interact with cholinergic neurones in its cataleptogenic action in the rat?", Neuropharmacology, 16 (12): 841–847, doi:10.1016/0028-3908(77)90146-0{{citation}}: CS1 maint: multiple names: authors list (link)
  15. ^ A. Pilc, B. Legutko, T. Frankiewicz, A. Czyrak (1994), "Trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate (trans-ACPD) stimulates cAMP accumulation in rat cerebral cortical slices but not in glial or neuronal cultures", Neuroscience Letters, 169 (1–2): 171–174, doi:10.1016/0304-3940(94)90383-2, PMID 8047276{{citation}}: CS1 maint: multiple names: authors list (link)
  16. ^ Karolina Podkowa, Bartłomiej Pochwat, Piotr Brański, Andrzej Pilc, Agnieszka Pałucha-Poniewiera (2016), "Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in rats", Psychopharmacology, 233 (15–16): 2901–2914, doi:10.1007/s00213-016-4325-7, PMC 4933730, PMID 27286960{{citation}}: CS1 maint: multiple names: authors list (link)
  17. ^ A. Kłodzińska, E. Chojnacka-Wójcik, A. Pałucha, P. Brański, P. Popik, A. Pilc (1999), "Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models", Neuropharmacology, 38 (12): 1831–1839, doi:10.1016/s0028-3908(99)00066-0, PMID 10608278{{citation}}: CS1 maint: multiple names: authors list (link)
  18. ^ Karolina Podkowa, Bartłomiej Pochwat, Piotr Brański, Andrzej Pilc, Agnieszka Pałucha-Poniewiera (2016), "Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in rats", Psychopharmacology, 233 (15–16): 2901–2914, doi:10.1007/s00213-016-4325-7, PMC 4933730, PMID 27286960{{citation}}: CS1 maint: multiple names: authors list (link)
  19. ^ Barbara Chruścicka-Smaga, Agata Machaczka, Bernadeta Szewczyk, Andrzej Pilc (2023), "Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies", Pharmacological Reports, 75 (6): 1341–1349, doi:10.1007/s43440-023-00547-4, PMC 10660980, PMID 37932583{{citation}}: CS1 maint: multiple names: authors list (link)
  20. ^ John P. A. Ioannidis, Kevin W. Boyack, Jeroen Baas (2020), "Updated science-wide author databases of standardized citation indicators", PLOS Biology, 18 (10): art. nr e3000918, doi:10.1371/journal.pbio.3000918, PMC 7567353, PMID 33064726{{citation}}: CS1 maint: multiple names: authors list (link)
  21. ^ "Polscy farmakolodzy i farmaceuci na liście TOP 2%" (in Polish). Forum Akademickie. 24 November 2023. Retrieved 2025-11-04.
  22. ^ Andrzej Pilc (2002), "Najczęściej cytowani naukowcy oraz prace naukowe w Polsce. Raport za lata 1965–2001 na podstawie bazy "Science Citation Inex" dotyczącej wszystkich światowych publikacji", Zagadnienia Naukoznawstwa: 65-82
  23. ^ "Królowie nauki". wprost.pl. 7 April 2002. Retrieved 2025-04-09.
  24. ^ "Nagroda im. Profesora Tadeusza Browicza". Portal Zarządzania Wiedzą UJ CM. Retrieved 2025-11-16.
  25. ^ "Nagroda im. Jędrzeja Śniadeckiego". Portal Zarządzania Wiedzą UJ CM. Retrieved 2025-11-16.
  26. ^ "Medal im. Jędrzeja Śniadeckiego". Portal Zarządzania Wiedzą UJ CM. Retrieved 2025-11-16.
  27. ^ "POSTANOWIENIE PREZYDENTA RZECZYPOSPOLITEJ POLSKIEJ z dnia 17 sierpnia 2004 r. o nadaniu orderu i odznaczeń". prawo.pl. Retrieved 2025-11-16.
  28. ^ "Najlepszy naukowiec z Polski wg rankingu Top Medicine Scientists". Portal Zarządzania Wiedzą UJ CM. Retrieved 2025-11-16.
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