Aldose-6-phosphate reductase (NADPH)
| aldose-6-phosphate reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.200 | ||||||||
| CAS no. | 76901-04-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, aldose-6-phosphate reductase (NADPH) (EC 1.1.1.200) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-sorbitol 6-phosphate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are D-glucose 6-phosphate (shown in open-chain aldehydo form), reduced NADPH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP+ 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP+-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP+ 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).
References