Acylglycerone-phosphate reductase
| acylglycerone-phosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.101 | ||||||||
| CAS no. | 37250-35-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction
1-palmitoylglycerol 3-phosphate
R=CH3(CH2)14
R=CH3(CH2)14
+ NADP+
H+
H+
palmitoylglycerone phosphate
R=CH3(CH2)14
R=CH3(CH2)14
+ NADPH
The substrate of this enzyme is an ester of the long-chain fatty acid, CH3(CH2)14COOH (palmitic acid), which reacts with oxidised nicotinamide adenine dinucleotide phosphate (NADP+). This converts the hydroxy group of the glycerol fragment to the corresponding ketone. The cofactor is converted to NADPH, and a proton is released.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.
References
- ^ Enzyme 1.1.1.101 at KEGG Pathway Database.
- ^ LaBelle EF, Hajra AK (September 1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". The Journal of Biological Chemistry. 247 (18): 5825–34. doi:10.1016/S0021-9258(19)44832-1. PMID 4403490.