21-hydroxysteroid dehydrogenase (NAD+)
| 21-hydroxysteroid dehydrogenase (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.150 | ||||||||
| CAS no. | 37250-75-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 21-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.150) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (5β)-pregnan-21-ol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are (5β)-pregnan-21-al, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NAD+ 21-oxidoreductase. This enzyme is also called 21-hydroxysteroid dehydrogenase (NAD+).
See also
- 21-hydroxysteroid dehydrogenase (NADP+), an enzyme which catalyses the same reaction but using an alternative cofactor
References
- ^ Enzyme 1.1.1.150 at KEGG Pathway Database.
- ^ Monder C, White A (1965). "The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases". J. Biol. Chem. 240: 71–7. doi:10.1016/S0021-9258(18)97617-9. PMID 14253469.