The 2010 South Dakota State Jackrabbits football team represented South Dakota State University as a member of the Missouri Valley Football Conference (MVFC) during the 2010 NCAA Division I FCS football season. Led by 14th-year head coach John Stiegelmeier, the Jackrabbits compiled an overall record of 5–6 with a mark of 4–4 in conference play, placing in a six-way tie for third in the MVFC. South Dakota State played their home games at Coughlin–Alumni Stadium in Brookings, South Dakota.
Schedule
| Date | Time | Opponent | Rank | Site | TV | Result | Attendance | Source |
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| September 11 | 12:00 pm | at No. 16 Delaware* | No. 9 | | | L 3–26 | 19,854 | |
| September 18 | 6:00 pm | Illinois State | No. 20 | | | L 14–24 | 12,425 | |
| September 25 | 6:00 pm | at No. 6 (FBS) Nebraska* | | | FSN PPV | L 3–17 | 85,573 | |
| October 2 | 4:05 pm | at No. 17 Northern Iowa | | | Mediacom, CFU Ch. 15 | L 14–24 | 14,686 | |
| October 9 | 4:05 pm | No. 20 Western Illinois | | - Coughlin–Alumni Stadium
- Brookings, SD
| | W 33–29 | 11,353 | |
| October 16 | 2:00 pm | at No. 17 Southern Illinois | | | | W 31–10 | 11,136 | |
| October 23 | 2:05 pm | Youngstown State | | - Coughlin–Alumni Stadium
- Brookings, SD
| | W 30–20 | 14,697 | |
| October 30 | 2:05 pm | at Indiana State | | | | L 30–41 | 5,347 | |
| November 6 | 1:00 pm | Missouri State | | - Coughlin–Alumni Stadium
- Brookings, SD
| | W 31–10 | 7,724 | [1] |
| November 13 | 3:10 pm | No. 24 North Dakota State | | | | L 24–31 | 17,037 | [2] |
| November 20 | 1:00 pm | North Dakota* | | - Coughlin–Alumni Stadium
- Brookings, SD
| | W 21–0 | 3,918 | |
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[3][4]
References
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| Venues | |
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| Bowls & rivalries | |
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| Culture & lore |
- Jack Rabbit
- "Ring the Bell"
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| People | |
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| Seasons | |
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National championship seasons in bold |