The 2010 Lenoir–Rhyne Bears football team represented Lenoir–Rhyne University in the 2010 NCAA Division II football season. The Bears offense scored 358 points while the defense allowed 223 points.
Schedule
| Date | Opponent | Site | Result | Attendance |
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| August 28 | Chowan* | | W 59–10 | 6,389 |
| September 4 | Concord* | - Moretz Stadium
- Hickory, NC
| L 17–20 | 6,298 |
| September 11 | Davidson* | - Moretz Stadium
- Hickory, NC
| W 41–13 | 7,081 |
| September 18 | at North Greenville* | | W 20–19 | 5,134 |
| October 2 | at Newberry | | L 36–40 | 3,012 |
| October 9 | Mars Hill | - Moretz Stadium
- Hickory, NC
| L 20–24 | 7,247 |
| October 16 | at Brevard | Brevard, NC | W 24–8 | 1,421 |
| October 23 | Tusculum | - Moretz Stadium
- Hickory, NC
| W 34–31 | 2,396 |
| October 30 | at Wingate | | L 24–27 | 3,913 |
| November 6 | at Carson–Newman | | W 52–14 | 3,864 |
| November 13 | Catawba | - Moretz Stadium
- Hickory, NC
| W 31–17 | 6,646 |
- *Non-conference game
- Homecoming
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References
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| Venues | |
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| Bowls & rivalries | |
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| Culture & lore | |
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| People | |
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| Seasons | |
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National championships in bold |