2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
| 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.126 | ||||||||
| CAS no. | 37250-55-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase (EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction
2-dehydro-3-deoxy-D-gluconic acid
+ NADP+
H+
H+
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid
+ NADPH
The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid, reduced NADPH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.
References
- ^ Enzyme 1.1.1.126 at KEGG Pathway Database.
- ^ Preiss J, Ashwell G (February 1962). "Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid". The Journal of Biological Chemistry. 237 (2): 317–21. doi:10.1016/S0021-9258(18)93921-9. PMID 14488585.